IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/Fowler

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Polymorphism of the human MUC genes

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1 Galton Laboratory, Department of Biology, Wolfson House, 4 Stephenson Way, London NW1 2HE
Front. Biosci. (Landmark Ed) 2001, 6(3), 1207–1215;
Published: 1 October 2001

Mucins encoded by the MUC genes share the common feature of having an extensive tandem repeat region that encompasses a large proportion of the coding sequence. In many of the genes this tandem repeat region shows a great deal of allelic length variation and recently studies have demonstrated person to person variation in pattern of nucleotide or amino-acid changes in the repeat units. The length and sequence variability will be discussed in this review, as will its role in disease susceptibility.

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