IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/A668

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Bromodomain motifs and "scaffolding"?
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1 Cancer Research Center, Boston University School of Medicine, Room L910, 80 East Concord Street, Boston, MA, USA 02118, USA

Academic Editor: Gerald Denis

Front. Biosci. (Landmark Ed) 2001, 6(3), 1065–1068; https://doi.org/10.2741/A668
Published: 1 September 2001
(This article belongs to the Special Issue The role of bromodomain proteins in the cell cycle and cancer)
Abstract

Bromodomain-containing multiprotein complexes share some of the properties of signal transduction scaffolds. Insights from MAP kinase signaling scaffolds, for example, may provide useful perspectives for future studies of bromodomain proteins. The regulatory processes of modification (phosphorylation, acetylation, ubiquitination), turnover, nuclear compartmentalization, feedback regulation and signaling pathway specificity are all likely to contribute to the mechanisms by which bromodomain-containing multiprotein complexes control transcription.

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