IMR Press / FBL / Volume 6 / Issue 3 / DOI: 10.2741/A597

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Gene targeting in hemostasis. Factor VII
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1 W.M. Keck Center for Transgene Research and the Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, USA
Front. Biosci. (Landmark Ed) 2001, 6(3), 98–104;
Published: 1 February 2001

Factor VII (FVII), in concert with its natural cofactor and receptor, Tissue Factor (TF), initiates the process of blood coagulation following vascular injury. Mice completely deficient in FVII were generated via specific deletion of exons 2 to 8, thus deleting the entire coding region of the mature protein. In contrast to the early lethality observed in TF-deficient embryos (TF-/-), embryos deficient in FVII (FVII-/-) developed normally, without incidence of hemorrhage. However, FVII-/- neonates succumbed to either early intraabdominal or intracranial hemorrhage in later life.

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