IMR Press / FBL / Volume 5 / Issue 3 / DOI: 10.2741/vink

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Regulation of intracellular free magnesium in central nervous system injury
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1 Department of Physiology and Pharmacology, James Cook University, Townsville, Queensland, 4811, Australia
Academic Editor:Hector Rasgado-Flores
Front. Biosci. (Landmark Ed) 2000, 5(3), 656–665;
Published: 1 August 2000
(This article belongs to the Special Issue Magnesium and cell proliferation and differentiation)

Traumatic injury to the central nervous system (CNS) initiates an autodestructive cascade of biochemical and pathophysiological changes that ultimately results in irreversible tissue damage. Known as secondary injury, this delayed injury process is multifactorial in nature and it is generally thought that the simultaneous attenuation of a number of the secondary injury factors will be required for interventional therapies to have a significant beneficial effect on outcome. This review summarizes the growing body of evidence that suggests that magnesium plays a pivotal role in the secondary injury process following CNS trauma, affecting a number of secondary injury factors including neurotransmitter release and activity, ion changes, oxidative stress, protein synthesis, and energy metabolism. By having effects on such a range of secondary injury factors following trauma, pharmacological studies have shown that magnesium may be an effective therapy following neurotrauma, improving survival, motor outcome and alleviating cognitive deficits.

Spinal Cord
Magnetic Resonance
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