IMR Press / FBL / Volume 5 / Issue 3 / DOI: 10.2741/ortiz

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Role and regulation of apoptotic cell death in the kidney. Y2K update
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1 Division of Nephrology. Fundacion Jimenez Diaz, Madrid, Spain
Front. Biosci. (Landmark Ed) 2000, 5(3), 735–749; https://doi.org/10.2741/ortiz
Published: 1 August 2000
Abstract

Apoptosis is an active form of cell death that, in balance with mitosis, regulates cell number. Cell number abnormalities are a frequent feature of renal disease. We now review current concepts on the molecular regulation of apoptotic cell death, including the influence of survival and lethal factors from the extracellular microenvironment as well as the role of intracellular regulators of apoptosis, such as death receptors, proapoptotic and antiapoptotic bcl2-related proteins, the mitochondria and caspases. In addition the role of apoptosis in the genesis, persistence and progression and remodeling and resolution of renal injury is discussed. Information on the expression and function of apoptosis regulatory proteins in specific renal syndromes is summarized. Finally, future perspectives in research and clinical intervention are discussed.

Keywords
Apoptosis
Cell death
Apo-1
Trail
Apo3
LT-1
TNF
TNF-receptor
Bcl2
BclxL
Bclw
Boo
A1
Mcl1
Bax
Bak
Bid
Bad
Bik
Bim
Hrk
Kidney
Review
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