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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Volume 5 Issue 3 2000
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- Open Access ArticleYeast perspectives on HIV-1 VPRYuqi Zhao, Robert T. ElderFront. Biosci. (Landmark Ed) 2000, 5(3), 905–916; https://doi.org/10.2741/zhao2Download18Citations2Views
- Open Access ArticleCell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycleBrian T. Zafonte, James Hulit, Derek F. Amanatullah, Chris Albanese, ... Richard G. PestellFront. Biosci. (Landmark Ed) 2000, 5(3), 938–961; https://doi.org/10.2741/zafonte(This article belongs to the Special Issue Cell cycle dysregulation in disease)24Download36Citations14Views
- Open Access ArticleBruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA)Mauno Vihinen, Pekka T. Mattsson, C. I. Edvard SmithFront. Biosci. (Landmark Ed) 2000, 5(3), 917–928; https://doi.org/10.2741/vihinen50Download20Citations17Views
- Open Access ArticleCaveolins in cholesterol trafficking and signal transduction: implications for human diseaseAmnon Schlegel, Richard G. Pestell, Michael P. LisantiFront. Biosci. (Landmark Ed) 2000, 5(3), 929–937; https://doi.org/10.2741/schlegel(This article belongs to the Special Issue Cell cycle dysregulation in disease)4Download38Citations4Views
- Open Access ArticleImmune regulation by CD40-CD40-l interactions - 2; Y2K updateCees van KootenFront. Biosci. (Landmark Ed) 2000, 5(3), 880–893; https://doi.org/10.2741/kooten9Download30Citations15Views
- Open Access ArticleThe physiology and psychology of selective attention to touchHeidi Johansen-Berg, Donna M LloydFront. Biosci. (Landmark Ed) 2000, 5(3), 894–904; https://doi.org/10.2741/berg(This article belongs to the Special Issue Congition and attention)4Download27Citations5Views
- Open Access ArticleProtein stability in extremophilic archaeaRoberto Scandurra, Valerio Consalvi, Roberta Chiaraluce, Laura Politi, Paul C. EngelFront. Biosci. (Landmark Ed) 2000, 5(3), 787–795; https://doi.org/10.2741/scan(This article belongs to the Special Issue Anti-stress mechanisms in archaea: implications for biology and medicine)1Download12Citations3Views
- Open Access ArticleOsmoadaptation and osmoregulation in archaeaMary F. RobertsFront. Biosci. (Landmark Ed) 2000, 5(3), 796–812; https://doi.org/10.2741/roberts(This article belongs to the Special Issue Anti-stress mechanisms in archaea: implications for biology and medicine)13Download32Citations9Views
- Open Access ArticlePlasmalemmal transport of magnesium in excitable cellsHector Rasgado-Flores, Hugo Gonzalez-SerratosFront. Biosci. (Landmark Ed) 2000, 5(3), 866–879; https://doi.org/10.2741/rasgado3Download6Citations4Views
- Open Access ArticleMolecular mechanisms regulating myogenic determination and differentiationRobert L.S. Perry, Michael A. RudnickFront. Biosci. (Landmark Ed) 2000, 5(3), 750–767; https://doi.org/10.2741/perry(This article belongs to the Special Issue Cellular and molecular aspects of muscle pathology)54Download126Citations170Views
- Open Access Article
Archaeal peptidyl prolyl cis-trans isomerases (PPIases)
Tadashi Maruyama, Masahiro FurutaniFront. Biosci. (Landmark Ed) 2000, 5(3), 821–836; https://doi.org/10.2741/maruyama(This article belongs to the Special Issue Anti-stress mechanisms in archaea: implications for biology and medicine)4Download10Citations3Views - Open Access ArticleStressors, stress and survival: overviewEverly Conway de Macario, Alberto J. L. MacarioFront. Biosci. (Landmark Ed) 2000, 5(3), 780–786; https://doi.org/10.2741/A550(This article belongs to the Special Issue Anti-stress mechanisms in archaea: implications for biology and medicine)8Download28Citations13Views
- Open Access ArticleProteasomes in the archaea: from structure to functionJulie A. Maupin-Furlow, Heather L. Wilson, Steven J. Kaczowka, Mark S. OuFront. Biosci. (Landmark Ed) 2000, 5(3), 837–865; https://doi.org/10.2741/furlow(This article belongs to the Special Issue Anti-stress mechanisms in archaea: implications for biology and medicine)15Download14Citations17Views
- Open Access ArticleOxygen: friend or foe? Archaeal superoxide dismutases in the protection of intra- and extracellular oxidative stressRaffaele Cannio, Gabriella Fiorentino, Alessandra Morana, Mosè Rossi, Simonetta BartolucciFront. Biosci. (Landmark Ed) 2000, 5(3), 768–779; https://doi.org/10.2741/cannio(This article belongs to the Special Issue Anti-stress mechanisms in archaea: implications for biology and medicine)7Download38Citations6Views
- Open Access ArticleAdaptations of the archaeal cell membrane to heat stressSonja-Verena Albers, Jack L.C.M. van de Vossenberg, Arnold J.M. Driessen, Wil N. KoningsFront. Biosci. (Landmark Ed) 2000, 5(3), 813–820; https://doi.org/10.2741/albers(This article belongs to the Special Issue Anti-stress mechanisms in archaea: implications for biology and medicine)67Download58Citations185Views
- Open Access ArticleRegulation of intracellular free magnesium in central nervous system injuryRobert Vink, Ibolja CernakFront. Biosci. (Landmark Ed) 2000, 5(3), 656–665; https://doi.org/10.2741/vink(This article belongs to the Special Issue Magnesium and cell proliferation and differentiation)6Download31Citations4Views
- Open Access ArticleSpecificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKABjørn S Skålhegg, Kjetil TaskenFront. Biosci. (Landmark Ed) 2000, 5(3), 678–693; https://doi.org/10.2741/skalhegg(This article belongs to the Special Issue Signaling through protein kinase C)93Download146Citations61Views
- Open Access ArticleMagnesium transport in the gastrointestinal tractM. Schweigel, H. MartensFront. Biosci. (Landmark Ed) 2000, 5(3), 666–677; https://doi.org/10.2741/schweigel(This article belongs to the Special Issue Magnesium and cell proliferation and differentiation)30Download27Citations15Views
- Open Access ArticleRegulation of cellular magnesiumAndrea M.P. Romani, Antonio ScarpaFront. Biosci. (Landmark Ed) 2000, 5(3), 720–734; https://doi.org/10.2741/romani(This article belongs to the Special Issue Magnesium and cell proliferation and differentiation)39Download191Citations23Views
- Open Access ArticleEpithelial magnesium transport and regulation by the kidneyGary A. Quamme, Christian de RouffignacFront. Biosci. (Landmark Ed) 2000, 5(3), 694–711; https://doi.org/10.2741/quamme(This article belongs to the Special Issue Magnesium and cell proliferation and differentiation)19Download57Citations8Views
- Open Access ArticleRole and regulation of apoptotic cell death in the kidney. Y2K updateAlberto Ortiz, Corina Lorz, Marina P. Catalan, Pilar Justo, Jesús EgidoFront. Biosci. (Landmark Ed) 2000, 5(3), 735–749; https://doi.org/10.2741/ortiz7Download11Citations7Views
- Open Access ArticleRenal handling of magnesium in fish: from whole animal to brush border membrane vesiclesKlaus W. BeyenbachFront. Biosci. (Landmark Ed) 2000, 5(3), 712–719; https://doi.org/10.2741/beyenbach(This article belongs to the Special Issue Magnesium and cell proliferation and differentiation)6Download11Citations8Views
- Open Access ArticleIntracellular magnesium: transport and regulation in epithelial secretory cellsMaria D. Yago, Mariano Mañas, Jaipaul SinghFront. Biosci. (Landmark Ed) 2000, 5(3), 602–618; https://doi.org/10.2741/yago(This article belongs to the Special Issue Magnesium and cell proliferation and differentiation)12Download21Citations12Views
- Open Access ArticleBiosynthesis and regulation of expression of proteoglycansNancy B. SchwartzFront. Biosci. (Landmark Ed) 2000, 5(3), 649–655; https://doi.org/10.2741/A54010Download45Citations4Views
- Open Access ArticleControl of vascular smooth muscle cell growth by cyclin-dependent kinase inhibitory proteins and its implication in cardiovascular diseaseSilvia M. Sanz-González, Enric Poch, Ignacio Pérez-Roger, Antonio Díez-Juan, ... Vicente AndrésFront. Biosci. (Landmark Ed) 2000, 5(3), 619–628; https://doi.org/10.2741/sanz(This article belongs to the Special Issue Eukaryotic cell cycle control)4Download19Citations6Views
- Open Access ArticleThe metabolism of quinone-containing alkylating agents: free radical production and measurementPeter L. GutierrezFront. Biosci. (Landmark Ed) 2000, 5(3), 629–638; https://doi.org/10.2741/gutier(This article belongs to the Special Issue Mechanisms of action of quinone-containing alkylating agents)11Download28Citations14Views
- Open Access ArticleMechanisms of action of quinone-containing alkylating agents. I: NQO1-directed drug developmentHoward D. Beall, Shannon L. WinskiFront. Biosci. (Landmark Ed) 2000, 5(3), 639–648; https://doi.org/10.2741/beall(This article belongs to the Special Issue Mechanisms of action of quinone-containing alkylating agents)7Download30Citations7Views
- Open Access ArticleClinical studies of antisense therapy in cancerAlan R. Yuen, Branimir I. SikicFront. Biosci. (Landmark Ed) 2000, 5(3), 588–593; https://doi.org/10.2741/yuen(This article belongs to the Special Issue Anti-sense therapeutics)2Download18Citations12Views
- Open Access ArticleCell cycle implications in the pathogenesis of rheumatoid arthritisMichael V. Volin, Alisa E. KochFront. Biosci. (Landmark Ed) 2000, 5(3), 594–601; https://doi.org/10.2741/volin(This article belongs to the Special Issue Cell cycle dysregulation in disease)2Download7Citations2Views
- Open Access ArticleCaloric restriction and immunosenescence: a current perspectiveMohammad A. PahlavaniFront. Biosci. (Landmark Ed) 2000, 5(3), 580–587; https://doi.org/10.2741/pahlavani13Download20Citations7Views
- Open Access ArticleProtein oxidation and age-dependent alterations in calcium homeostasisThomas C. Squier, Diana J. BigelowFront. Biosci. (Landmark Ed) 2000, 5(3), 504–526; https://doi.org/10.2741/squier13Download82Citations9Views
- Open Access ArticlePotential nuclease-based strategies for HIV gene therapyS Singwi, S JoshiFront. Biosci. (Landmark Ed) 2000, 5(3), 556–579; https://doi.org/10.2741/singwi3Download9Citations7Views
- Open Access ArticleCell cycle control in growth plate chondrocytesP LuValle, F BeierFront. Biosci. (Landmark Ed) 2000, 5(3), 493–503; https://doi.org/10.2741/luvalle(This article belongs to the Special Issue Cell cycle dysregulation in disease)5Download15Citations2Views
- Open Access ArticleCurrent developments and future prospects for HIV gene therapy using interfering RNA-based strategiesB Lamothe, S JoshiFront. Biosci. (Landmark Ed) 2000, 5(3), 527–555; https://doi.org/10.2741/lamothe(This article belongs to the Special Issue New and emerging targets for antiviral therapy)1Download12Citations0Views
- Open Access ArticleThe development and biology of bradyzoites of Toxoplasma gondiiL M Weiss, K KimFront. Biosci. (Landmark Ed) 2000, 5(3), 391–405; https://doi.org/10.2741/weiss25Download105Citations23Views
- Open Access ArticleTumor suppressor p53: regulation and functionK SomasundaramFront. Biosci. (Landmark Ed) 2000, 5(3), 424–437; https://doi.org/10.2741/somasund(This article belongs to the Special Issue Eukaryotic cell cycle control)24Download90Citations16Views
- Open Access ArticleMechanisms of interferon-induced cell cycle arrestO Sangfelt, S Erickson, D GranderFront. Biosci. (Landmark Ed) 2000, 5(3), 479–487; https://doi.org/10.2741/sangfelt(This article belongs to the Special Issue Cell cycle dysregulation in disease)55Download48Citations31Views
- Open Access ArticleCell cycle molecules and diseases of the cardiovascular systemS B Petkova, A Ashton, B Bouzahzah, H Huang, ... H B TanowitzFront. Biosci. (Landmark Ed) 2000, 5(3), 452–460; https://doi.org/10.2741/petkova(This article belongs to the Special Issue Cell cycle dysregulation in disease)3Download20Citations3Views
- Open Access ArticleReprogramming erythroleuekmia cells to terminal differentiation and terminal cell divisionI Matushansky, F Radparvar, N Rekhtman, A SkoultchiFront. Biosci. (Landmark Ed) 2000, 5(3), 488–492; https://doi.org/10.2741/matushan(This article belongs to the Special Issue Carbohydrates in immunology evolution of the immune system in particular MHC)1Download11Citations1Views
- Open Access ArticleThe neurobiology of attention-deficit hyperactivity disorderJ Himelstein, J H Newcorn, J M HalperinFront. Biosci. (Landmark Ed) 2000, 5(3), 461–478; https://doi.org/10.2741/himelste(This article belongs to the Special Issue Congition and attention)16Download59Citations27Views
- Open Access ArticleBETA 2 integrin signaling in leukocytesK DibFront. Biosci. (Landmark Ed) 2000, 5(3), 438–451; https://doi.org/10.2741/pathology(This article belongs to the Special Issue Integrins, cell migration and extracellular matrix)10Download24Citations8Views
- Open Access ArticleProtein kinase C-mediated regulation of the cell cycleJ D BlackFront. Biosci. (Landmark Ed) 2000, 5(3), 406–423; https://doi.org/10.2741/black(This article belongs to the Special Issue Eukaryotic cell cycle control)10Download77Citations10Views
- Open Access ArticleCell-cycle dysregulation and the molecular mechanisms of prostate cancerD F Amanatullah, A T Reutens, B T Zafonte, M Fu, ... R G PestellFront. Biosci. (Landmark Ed) 2000, 5(3), 372–390; https://doi.org/10.2741/amanatullah(This article belongs to the Special Issue Cell cycle dysregulation in disease)3Download33Citations1Views
- Open Access ArticleLuteinizing hormone receptor mutations in disorders of sexual development and cancerS M Wu, E W Leschek, O M Rennert, W Y ChanFront. Biosci. (Landmark Ed) 2000, 5(3), 343–352; https://doi.org/10.2741/wu(This article belongs to the Special Issue Genetic diseases)11Download34Citations66Views
- Open Access ArticleProgress in molecular genetics of autosomal dominant polycystic kidney diseaseM Trudel, R GuillaumeFront. Biosci. (Landmark Ed) 2000, 5(3), 312–320; https://doi.org/10.2741/trudel1Views
- Open Access ArticleGenetics of Carney complex and related familial lentiginoses, and other multiple tumor syndromesC A StratakisFront. Biosci. (Landmark Ed) 2000, 5(3), 353–366; https://doi.org/10.2741/stratakis(This article belongs to the Special Issue Genetic diseases)7Download20Citations5Views
- Open Access ArticleMolecular genetics of holoprosencephalyL Nanni, R L Schelper, M T MuenkeFront. Biosci. (Landmark Ed) 2000, 5(3), 334–342; https://doi.org/10.2741/nanni15Download23Citations8Views
- Open Access ArticleMolecular genetics of peroxisomal disordersH W MoserFront. Biosci. (Landmark Ed) 2000, 5(3), 298–306; https://doi.org/10.2741/moser(This article belongs to the Special Issue Genetic diseases)1Download16Citations6Views
- Open Access ArticleSpongy degeneration of the brain, Canavan disease: biochemical and molecular findingsR M Matalon, K Michals-MatalonFront. Biosci. (Landmark Ed) 2000, 5(3), 307–311; https://doi.org/10.2741/matalon(This article belongs to the Special Issue Genetic diseases)21Download18Citations12Views
- Open Access ArticleCyclin D1 in parathyroid diseaseS M Mallya, A ArnoldFront. Biosci. (Landmark Ed) 2000, 5(3), 367–371; https://doi.org/10.2741/mallya(This article belongs to the Special Issue Cell cycle dysregulation in disease)11Download33Citations10Views
- Open Access ArticleRecent advances in the understanding of genetic causes of congenital heart defectsB D GelbFront. Biosci. (Landmark Ed) 2000, 5(3), 321–333; https://doi.org/10.2741/gelb(This article belongs to the Special Issue Genetic diseases)4Download2Citations4Views
- Open Access ArticleInteractions of HIV-1 NEF with cellular signal transducing proteinsG H Renkema, K SakselaFront. Biosci. (Landmark Ed) 2000, 5(3), 268–283; https://doi.org/10.2741/renkema(This article belongs to the Special Issue New and emerging targets for antiviral therapy)3Download121Citations5Views
- Open Access ArticleMitogen-activated signaling and cell cycle regulation in airway smooth muscleK Page, M B HershensonFront. Biosci. (Landmark Ed) 2000, 5(3), 258–267; https://doi.org/10.2741/page(This article belongs to the Special Issue Cell cycle dysregulation in disease)2Download22Citations2Views
- Open Access ArticleModulations of primary visual cortex activity representing attentive and conscious scene perceptionV A Lamme, H SpekreijseFront. Biosci. (Landmark Ed) 2000, 5(3), 232–243; https://doi.org/10.2741/lamme(This article belongs to the Special Issue Congition and attention)6Download22Citations6Views
- Open Access ArticleVisual attention and agingK E Groth, P A AllenFront. Biosci. (Landmark Ed) 2000, 5(3), 284–297; https://doi.org/10.2741/groth(This article belongs to the Special Issue Congition and attention)33Download17Citations21Views
- Open Access ArticleCell cycle regulation and RNA polymerase IID B Bregman, R G Pestell, V J KiddFront. Biosci. (Landmark Ed) 2000, 5(3), 244–257; https://doi.org/10.2741/bregman(This article belongs to the Special Issue Cell cycle dysregulation in disease)29Download44Citations15Views
- Open Access ArticleHuman T cell lymphotropic virus type I genomic expression and impact on intracellular signaling pathways during neurodegenerative disease and leukemiaJ Yao, B WigdahlFront. Biosci. (Landmark Ed) 2000, 5(3), 138–168; https://doi.org/10.2741/yao3Download25Citations6Views
- Open Access ArticleBacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigmM E TolmaskyFront. Biosci. (Landmark Ed) 2000, 5(3), 20–29; https://doi.org/10.2741/tolmasky(This article belongs to the Special Issue Bacterial resistance to aminoglycoside and beta-lactam antibiotics: molecular genetics and dissemination)5Download7Citations10Views
- Open Access ArticleRole of pRB dephosphorylation in cell cycle regulationS Tamrakar, E Rubin, J W LudlowFront. Biosci. (Landmark Ed) 2000, 5(3), 121–137; https://doi.org/10.2741/tamrakar(This article belongs to the Special Issue Cellular functions of protein phosphatases)41Download71Citations15Views
- Open Access ArticleGenetic alterations in adult diffuse glioma: occurrence, significance, and prognostic implicationsJ S Smith, R B JenkinsFront. Biosci. (Landmark Ed) 2000, 5(3), 213–231; https://doi.org/10.2741/smith(This article belongs to the Special Issue Encyclopedia of neuro-oncology)8Download104Citations10Views
- Open Access ArticleTheoretical and experimental approaches to design effective antisense oligonucleotidesG SczakielFront. Biosci. (Landmark Ed) 2000, 5(3), 194–201; https://doi.org/10.2741/sczakiel(This article belongs to the Special Issue Anti-sense therapeutics)6Download10Citations2Views
- Open Access ArticleCell cycle control of pancreatic beta cell proliferationS G Rane, E P ReddyFront. Biosci. (Landmark Ed) 2000, 5(3), 1–19; https://doi.org/10.2741/rane(This article belongs to the Special Issue Eukaryotic cell cycle control)20Download21Citations7Views
- Open Access ArticleVisual search: bottom-up or top-down?G A Patel, K SathianFront. Biosci. (Landmark Ed) 2000, 5(3), 169–193; https://doi.org/10.2741/A503(This article belongs to the Special Issue Congition and attention)8Download11Citations6Views
- Open Access ArticleCentripetal versus centrifugal bias in visual line bisection: focusing attention on two hypothesesM E McCourt, M Garlinghouse, J SlaterFront. Biosci. (Landmark Ed) 2000, 5(3), 58–71; https://doi.org/10.2741/A496(This article belongs to the Special Issue Congition and attention)1Download36Citations1Views
- Open Access ArticleThe control of mitosisM L Hixon, A GualbertoFront. Biosci. (Landmark Ed) 2000, 5(3), 50–57; https://doi.org/10.2741/hixon(This article belongs to the Special Issue Eukaryotic cell cycle control)19Download5Citations18Views
- Open Access ArticleCellular and molecular basis of beta-amyloid precursor protein metabolismJ P Greenfield, R S Gross, G K Gouras, H XuFront. Biosci. (Landmark Ed) 2000, 5(3), 72–83; https://doi.org/10.2741/greenfield5Download34Citations4Views
- Open Access ArticleThe development of auditory attention in childrenH Gomes, S Molholm, C Christodoulou, W Ritter, N CowanFront. Biosci. (Landmark Ed) 2000, 5(3), 108–120; https://doi.org/10.2741/gomes(This article belongs to the Special Issue Congition and attention)38Download51Citations34Views
- Open Access ArticleNeurophysiological mechanisms of auditory selective attention in humansM H Giard, A Fort, Y Mouchetant-Rostaing, J PernierFront. Biosci. (Landmark Ed) 2000, 5(3), 84–94; https://doi.org/10.2741/giard(This article belongs to the Special Issue Congition and attention)22Download61Citations15Views
- Open Access ArticlePathogenesis and treatment of HIV-1 infection: recent developments (Y2K update)S L Dewhurst, R L da Cruz, L WhetterFront. Biosci. (Landmark Ed) 2000, 5(3), 30–49; https://doi.org/10.2741/A494(This article belongs to the Special Issue New and emerging targets for antiviral therapy)4Download3Citations1Views
- Open Access ArticleMultiple facets of sialomucin complex/MUC4, a membrane mucin and erbb2 ligand, in tumors and tissues (Y2K update)K L Carraway, S A Price-Schiavi, M Komatsu, N Idris, ... C A CarrawayFront. Biosci. (Landmark Ed) 2000, 5(3), 95–107; https://doi.org/10.2741/carraway5Download19Citations2Views
- Open Access ArticleSelectively attending to auditory objectsC Alain, S R ArnottFront. Biosci. (Landmark Ed) 2000, 5(3), 202–212; https://doi.org/10.2741/alain(This article belongs to the Special Issue Congition and attention)12Download79Citations33Views