IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/graves

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The expression of monocyte chemoattractant protein-1 and other chemokines by osteoblasts
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1 Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
2 Department of Endodontics, Boston University School of Dental Medicine, Boston, MA 02118, USA
3 Department of Medicine, University of Texas Health Science Center, San Antonio, Texas,USA
Academic Editor:Kenth Gustafsson
Front. Biosci. (Landmark Ed) 1999, 4(4), 571–580; https://doi.org/10.2741/graves
Published: 1 July 1999
Abstract

Chemokines are low molecular weight secretory proteins that function principally as stimulators of leukocyte recruitment. There are four defined chemokine subfamilies based on their primary structure, CXC, CC, C and CX3C. Members of the CC chemokine subfamily, a such as monocyte chemoattractant protein 1 (MCP-1) are chemotactic for monocytes and other leukocyte subsets. Because monocytes produce factors that regulate bone formation or resorption, such as PDGF, IL-1 or TNF, chemokines that initiate their recruitment are likely to be important in regulating osseous metabolism. In the studies below, data is presented demonstrating mechanisms of MCP-1 expression in osteoblastic cells. These studies establish that MCP-1 is induced during osseous inflammation and in developmentally regulated bone remodelling, and is associated with enhanced monocyte recruitment when applied to osseous lesions.

Keywords
Bone
Chemokine
Cytokine
Osteoblast
Osteoclast
Osseous
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