IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/garcia

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function
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1 Ludwig Institute for Cancer Research, University of California San Diego, 9500 Gilman Drive, La Jolla, CA
2 Department of Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Clinic/Foundation, 200 First Street SW, Rochester, MN 55905
Front. Biosci. (Landmark Ed) 1999, 4(4), 869–882; https://doi.org/10.2741/garcia
Published: 1 December 1999
Abstract

The plasma membrane calcium ATPases (PMCAs) are ubiquitously expressed proteins that couple the extrusion of calcium across the plasma membrane with the hydrolysis of ATP. In mammals, four separate genes encode distinct PMCA isoforms. Complex patterns of alternative RNA splicing generate additional isoform variability. Functionally, the PMCAs were originally assigned the role of maintaining basal levels of intracellular calcium. Recent evidence, however, is expanding the role of the PMCAs as important participants in dynamic Ca2+ regulation and as crucial players of Ca2+ export during normal and pathological conditions. This review highlights recent advances made on the biology of the PMCAs within the context of neuronal development, cellular responses to external stimuli and cell survival. Particular emphasis is placed on the role of the PMCAs in vestibular and auditory functions, localized calcium signaling in photoreceptor synaptic terminals and calcium-mediated cell death.

Keywords
Auditory system
calcium homeostasis
calcium pump
calcium signaling
calcium transport
cell death
cochlea
excitotoxicity
photoreceptors
PC12 cells
P-type ATPase
sensory hair cells
Review
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