IMR Press / FBL / Volume 4 / Issue 4 / DOI: 10.2741/boddy

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
DNA replication checkpoint control
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1 Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Academic Editor:Hisao Masai
Front. Biosci. (Landmark Ed) 1999, 4(4), 841–848; https://doi.org/10.2741/boddy
Published: 1 December 1999
(This article belongs to the Special Issue DNA replication mechanisms and regulation)
Abstract

The eukaryotic cell cycle comprises two critical phases, DNA replication (S phase) and the subsequent distribution of an equivalent genome to each of two daughter cells at mitosis (M phase). A signal transduction cascade called the replication checkpoint has evolved to ensure that M phase does not occur prior to the completion of S phase. The mitotic regulators targeted by this checkpoint have recently been identified in the fission yeast Schizosaccharomyces pombe. As was the case for the DNA damage checkpoint, studies on the replication checkpoint in fission yeast promise to provide an excellent framework for analogous studies in mammalian cells.

Keywords
Replication
Checkpoint
Cds1
Chk1
Mitosis
Review
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