IMR Press / FBL / Volume 3 / Issue 5 / DOI: 10.2741/A366

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Testis-specific proteins and their role in contraceptive vaccine development
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1 Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Richard D. Ruppert Health Center, 3120 Glendale Avenue, Toledo, OH 43614-5809, USA

Academic Editor: Rajesh K. Naz

Front. Biosci. (Landmark Ed) 1998, 3(5), 39–48;
Published: 30 April 1998
(This article belongs to the Special Issue Male reproductive medicine)

Development of a vaccine(s) based on sperm antigens represents a promising approach for contraception. The utility of an antigen in immunocontraception is contingent upon its testis/sperm specificity and involvement in spermatogenesis and/or fertilization. The aim of the present article is to review the information regarding the proteins that have been reported to be testis/sperm-specific and may have an important function in spermatogenesis and/or fertilization. The potential role of these proteins in the development an antisperm contraceptive vaccine(s) is discussed.

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