IMR Press / FBL / Volume 3 / Issue 4 / DOI: 10.2741/A349

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

T cell signaling: effect of age
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1 Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System and Department of Physiology, University of Texas Health Science Center, San Antonio, Texas 78284

Academic Editor: Kenth Gustafsson

Front. Biosci. (Landmark Ed) 1998, 3(4), 1120–1133;
Published: 1 November 1998

Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is poorly understood. The available data suggest that changes in the signal transduction machinery are responsible for the impairment of T cell function during aging. T cell activation is initiated when an antigenic peptide is recognized by the antigen receptor of T cells. This recognition event promotes sequential activation of a network of signaling molecules such as kinases, phosphatates, and adaptor proteins that couple the stimulatory signal received from T cell receptor (TCR) to intracellular signaling pathways. The coordinate activation of these signaling molecules is sufficient to stimulate the activation of transcription factors and the expression of the immediate-early genes that are crucial in regulation of T cell function.

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