IMR Press / FBL / Volume 3 / Issue 4 / DOI: 10.2741/A309

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
The CD44 protein family: roles in embryogenesis and tumor progression
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1 University of Karlsruhe, Institute of Genetics Postfach 3640 D-76021 Karlsruhe, Germany, genetik@igen.fzk.de
2 University of Karlsruhe, Institute of Genetics Postfach 3640 D-76021 Karlsruhe, Germany, genetik
Front. Biosci. (Landmark Ed) 1998, 3(4), 650–656; https://doi.org/10.2741/A309
Published: 1 July 1998
Abstract

Members of the CD44 protein family are engaged in various physiological and pathological processes such as lymphocyte activation, lymphocyte homing, wound healing, delayed type hypersensitivity, apoptosis, tumor progression and limb development. Here we summarize observations which lead to a molecular understanding of the function of CD44 in some of these physiological processes. The most striking function for a CD44 variant protein is its presentation of growth factors to high affinity receptors on mesenchymal cells in the developing limb. Furthermore we summarize the experiments that allowed the identification of CD44 variant exon encoded sequences which account for differentiation-specific and inducible splice regulation.

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