IMR Press / FBL / Volume 3 / Issue 4 / DOI: 10.2741/A276

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Regulation of survival pathways by IL-3 and induction of apoptosis following IL-3 withdrawal
Show Less
1 Departments of Medicine and Pharmacology, University of Pittsburgh, and the University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

Academic Editor: Adriana Heguy

Front. Biosci. (Landmark Ed) 1998, 3(4), 313–324;
Published: 15 March 1998
(This article belongs to the Special Issue New and emerging targets for antiviral therapy)

The production of hematopoietic cells is regulated by the availability of key cytokines such as interleukin-3 (IL-3). IL-3 promotes the survival and proliferation of bone marrow-derived hematopoietic cells. Recent studies using IL-3-dependent cell lines have begun to shed light on the regulation of apoptosis in cytokine-dependent cells. These studies indicate that IL-3 inhibits apoptosis by stimulating the activation of cellular kinases, including phophatidylinositol (PI) 3-kinase and Akt kinase. On the other hand, withdrawal of IL-3 leads to the activation of caspase proteases and a commitment to cell death. This review will discuss the current state of knowledge regarding the molecular mechanisms of: a) suppression of apoptosis by IL-3, and b) activation of apoptosis following IL-3 withdrawal.

Back to top