IMR Press / FBL / Volume 3 / Issue 4 / DOI: 10.2741/A276

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Regulation of survival pathways by IL-3 and induction of apoptosis following IL-3 withdrawal
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1 Departments of Medicine and Pharmacology, University of Pittsburgh, and the University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Front. Biosci. (Landmark Ed) 1998, 3(4), 313–324;
Published: 15 March 1998

The production of hematopoietic cells is regulated by the availability of key cytokines such as interleukin-3 (IL-3). IL-3 promotes the survival and proliferation of bone marrow-derived hematopoietic cells. Recent studies using IL-3-dependent cell lines have begun to shed light on the regulation of apoptosis in cytokine-dependent cells. These studies indicate that IL-3 inhibits apoptosis by stimulating the activation of cellular kinases, including phophatidylinositol (PI) 3-kinase and Akt kinase. On the other hand, withdrawal of IL-3 leads to the activation of caspase proteases and a commitment to cell death. This review will discuss the current state of knowledge regarding the molecular mechanisms of: a) suppression of apoptosis by IL-3, and b) activation of apoptosis following IL-3 withdrawal.

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