Tumour metastasis to the brain is a complex process involving crosstalk between
the circulating tumour cells and the blood brain barrier (BBB). Astrocytes, which
reside in the abluminal surface of the microvasculature of the BBB, are now known
to play an essential role in tumour cell migration and invasion into the brain
parenchyma. For instance, pro-inflammatory astrocyte secretions, including
TNF-
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The role of astrocytes in brain metastasis at the interface of circulating tumour cells and the blood brain barrier
Layla Burn1, Nicholas Gutowski2,3, Jacqueline Whatmore2, Georgios Giamas1,*, Md Zahidul Islam Pranjol1,*
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1
School of Life Sciences, University of Sussex, BN1 9QG Falmer, Brighton, UK
2
College of Medicine and Health, University of Exeter, EX1 2LU Exeter, Devon, UK
3
Royal Devon and Exeter NHS Foundation Trust, EX2 7JU Exeter, Devon, UK
*Correspondence: g.giamas@sussex.ac.uk (Georgios Giamas); Z.Pranjol@sussex.ac.uk (Md Zahidul Islam Pranjol)
Front. Biosci. (Landmark Ed) 2021, 26(9), 590–601;
https://doi.org/10.52586/4969
Submitted: 22 June 2021 | Revised: 19 July 2021 | Accepted: 4 August 2021 | Published: 30 September 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Astrocytes
Blood brain barrier
Metastasis
Endothelium
Figures
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