Jinwei Zhang. The long and short of it: long noncoding RNAs in neural development and diseases. Front. Biosci. (Landmark Ed)2021, 26(8), 258–261.
A simplified view of regulatory lncRNA functions in neural
development and pathology. (A) Multi-domain secondary structure of an envisioned
lncRNA, featuring numerous hairpin stem loops, single-stranded regions,
multi-helix junctions, compact domains harboring tertiary folds, long-range
interactions such as pseudoknots, etc. (B) Diagram of neural development
regulation by representative lncRNAs. Depicted are lncRNA-regulated developmental
phases of neural stem cell self-renewal (left), commitment to differentiation
(middle), and synaptogenesis and synaptic plasticity (right).