Intestinal and hepatic lipid metabolism plays an essential role in regulating
plasma lipid levels. These lipids are mobilized on apolipoprotein B
(apoB)-containing lipoproteins and their plasma homeostasis is maintained by
balancing production and catabolism. Microsomal triglyceride transfer protein
(MTP) which is expressed mainly in the intestine and liver plays an essential
role in regulating the assembly and secretion of apoB-lipoproteins. Any imbalance
in the production or clearance of lipoproteins leads to hyperlipidemia which is a
major risk factor for atherosclerosis, obesity, diabetes, and metabolic syndrome.
Here, we identify a new role of inositol-requiring transmembrane
kinase/endoribonuclease 1
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Original Research
Diet-induced differential effects on plasma lipids secretion by the inositol-requiring transmembrane kinase/endoribonuclease 1
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1
King Abdullah International Medical Research Center (KAIMRC)-Eastern Region, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdulaziz Hospital (KAH), Ministry of National Guard-Health Affairs (MNG-HA), 31982 Al Ahsa, Saudi Arabia
2
Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
*Correspondence: iqbalja@ngha.med.sa (Jahangir Iqbal)
Front. Biosci. (Landmark Ed) 2021, 26(5), 11–21;
https://doi.org/10.52586/4920
Submitted: 28 September 2020 | Accepted: 25 February 2021 | Published: 30 April 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Lipoproteins
Lipids
Atherosclerosis
Obesity
Diabetes
Endoplasmic reticulum
Unfolded protein response
Microsomal triglyceride transfer protein
Inositol-requiring transmembrane kinase/endoribonuclease 1
Inositol-requiring transmembrane kinase/endoribonuclease 1
Figures
Fig. 1.