IMR Press / FBL / Volume 26 / Issue 4 / DOI: 10.2741/4910

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Association between nitrated lipoproteins and vascular function in type 2 diabetes
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1 State University of New York, Downstate Medical Center, Department of Medicine, 450 Clarkson Ave., Brooklyn, New York 11203, USA
2 SUNY Downstate Health Sciences University, School of Public Health, Department of Epidemiology and Biostatistics, 450 Clarkson Ave., Brooklyn, New York 11203, USA
3 King Abdullah International Medical Research Center (KAIMRC), and King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of National Guard Health Affairs, Al Ahsa 31982, Saudi Arabia
Send correspondence to Ahmed Bakillah, Department of Medicine, SUNY Downstate Medical Center, 450 Clarkson Ave, Mail Stop 50, Brooklyn, NY 11203, Tel: 718-270-2216, Fax: 718-270-3899, E-mail:
Front. Biosci. (Landmark Ed) 2021, 26(4), 644–663;
Published: 1 October 2020

Higher levels of nitrated lipoproteins (NT-HDL and NT-LDL) were found in blood and atherosclerotic plaques of patients with coronary artery disease. We aimed to examine the relationship between plasma NT-HDL and NT-LDL and diabetic vascular dysfunction. The study included 125 African-American patients with T2DM. NT-HDL and NT-LDL were quantified by ELISA. Microvascular function was assessed by vascular reactivity index (VRI). Large artery stiffness was assessed by carotid-femoral pulse wave velocity (PWV). Carotid intima-media thickness (CIMT) was assessed by B-mode ultrasound imaging. In univariate analysis, NT-HDL was associated with VRI in total population and in patients with HbA1c ≤7.0% (β= -0.178, p= 0.034; β= -0.265, p= 0.042; respectively). In contrast, NT-LDL was associated with CIMT in total population and in patients with HbA1c >7.0% (β= -0.205, p= 0.022; β= -0.244, p= 0.042; respectively). Multivariable-adjusted regression analysis demonstrated that NT-HDL independently predicted VRI outcome in total population and in well-controlled patients (β= -0.282, p= 0.014; β= -0.400, p= 0.035, respectively). These results suggest that NT-HDL could be used as marker to identify diabetic patients at risk of developing early microvascular complications.

Cardiovascular disease
Endothelium function
Nitric oxide
Vascular complications
Type 2 diabetes
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