IMR Press / FBL / Volume 26 / Issue 3 / DOI: 10.2741/4908

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD
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1 Department of Behavioral Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khoud 123, Muscat, Oman
2 Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman
3 Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman
4 Research and Policy Department, World Innovation Summit for Health (WISH), Qatar Foundation, P.O. Box 5825, Doha, Qatar
Send correspondence to: Samir Al Adawi, Department of Behavioral Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khoud 123, Muscat, Oman, Tel: 968-2414-1139, Fax 968-2441-3419, E-mail:
Front. Biosci. (Landmark Ed) 2021, 26(3), 566–611;
Published: 1 October 2020

Vitamin D deficiency has been estimated to affect roughly 30% to 50% of the global population and thus labeled as a silent pandemic. In addition to its role in skeletal and calcium homeostasis, vitamin D has been implicated in brain functioning across both preclinical research and human populations studies. These findings have also been extended to various neurodevelopmental and neuropsychiatric conditions. Furthermore, these individuals tend to display diminishing cognition symptoms. In this regard, this review is dedicated to address the relationship between vitamin D and dementia, mood disorders, and the various neuropsychological disorders of psychosis. The review takes both preclinical and clinical studies into consideration. While there are many literature suggesting the critical role of vitamins in cognition on the above said diseases, it is still premature to unequivocally postulate the role of vitamin D on cognitive symptoms. Further research is necessary to establish this association, including the need to increase the ecological validity of animal models, delineating the core cognitive symptoms associated with the disorders, and establishing the optimal source of vitamin D consumption.

Vitamin D
Brain health
Brain development
Neurological disorders
Cognitive impairment
Neuropsychological impairment
Depression disorders
Neuropsychological functioning
Attention-deficit hyperactivity disorder
Figure 1
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