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IMR Press / FBL / Volume 26 / Issue 12 / DOI: 10.52586/5061
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Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target
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1 Department of General Surgery, Peking University First Hospital, 100034 Beijing, China

Front. Biosci. (Landmark Ed) 2021, 26(12), 1689–1696; https://doi.org/10.52586/5061
Submitted: 12 September 2021 | Revised: 13 October 2021 | Accepted: 28 October 2021 | Published: 30 December 2021
(This article belongs to the Special Issue Novel Approaches to Cancer Diagnosis and Therapy)
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract

Pancreatic cancer is still one of the most perilous malignant tumors with a very poor prognosis. Despite the progress in the diagnosis and treatment of pancreatic cancer, the overall 5-year survival rate after diagnosis is less than 10%. The pathogenesis of pancreatic cancer has not been fully clarified, but multiple factors are involved. The poor efficacy of traditional therapies for pancreatic cancer is mainly related to complex tumor microenvironment. In recent years, accumulating studies have demonstrated the role of autophagy and apoptosis triggered by endoplasmic reticulum stress in pancreatic cancer. In particular, unfolded protein response is activated by endoplasmic reticulum stress and plays an important role in the modulation of complex pancreatic tumor microenvironment. Here we summarize recent progress in our understanding of the role of unfolded protein response activated by endoplasmic reticulum stress in tumorigenesis of pancreatic cancer, and highlight the potential of the cascade of unfolded protein response as therapeutic target for pancreatic cancer.

Keywords
Endoplasmic reticulum stress
Unfolded protein response
Pancreatic cancer
Apoptosis
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