IMR Press / FBL / Volume 26 / Issue 12 / DOI: 10.52586/5059
Open Access Review
Pathways in small cell lung cancer and its therapeutic perspectives
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1 Department of Applied Sciences, Indian Institute of Information Technology Allahabad, 211012 Allahabad, India
2 Department of Biotechnology, National Institute of Technology Durgapur, 713209 Durgapur, West Bengal, India
3 Department of Studies in Biotechnology, University of Mysore, 570005 Mysore, Karnataka, India
4 Redox Regulation Laboratory, Department of Zoology, Odisha University of Agriculture and Technology, College of Basic Science and Humanities, 751003 Bhubaneswar, Odisha, India
*Correspondence: (Biswaranjan Paital); (Pritish Kumar Varadwaj); (Sintu Kumar Samanta)
Academic Editor: Graham Pawelec
Front. Biosci. (Landmark Ed) 2021, 26(12), 1668–1678;
Submitted: 7 July 2021 | Revised: 16 November 2021 | Accepted: 23 November 2021 | Published: 30 December 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (

Small cell lung cancer (SCLC) is known for its rapid growth with high metastatic spread. Its treatment remains a major challenge for oncologists due to the high mutation rate and other clinical disadvantages. The survival rate of these patients is very poor but there is no significant progress over the last few decades in the treatment protocols. Hence there is an urgency to design new clinical trials with novel drug combinations that can specifically and effectively target key pathways for proper treatment of SCLC. There have been several indications that developmental signalling pathways are involved in tumor growth, progression, metastasis and invasion of SCLC. Thus, it is anticipated that deciphering the signalling cascades of these embryonic signalling pathways may reveal novel therapeutic breakthroughs in SCLC. In this context, we have tried to assemble all the relevant information to give an updated overview of the various signalling pathways involved in the development of SCLC.

Small cell lung cancer
Signalling pathways
Notch pathway
FGF pathway
Hedgehog pathway
Fig. 1.
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