Academic Editor: Indrajit Chowdhury
Introduction: Myocardial infarction is the leading cause of death in
women worldwide. Several studies have shown that estrogens play a
cardioprotective role in women by decreasing reactive oxygen species (ROS) and
increasing nitric oxide (NO). The aim of this work was to determine whether the
evolution of myocardial infarction depends on the phase of the estrous cycle.
Methods: Female Wistar rats were randomized into the following groups
with an (n = 7 per group): (1) ovariectomized (OVX-sham); (2) OVX-48 h coronary
occlusion (CO); (3) OVX-2 w CO; (4) proestrus-sham; (5) proestrus-48 h CO; (6)
proestrus-2 w CO; (7) estrus-sham; (8) estrus-48 h CO; and (9) estrus-2 w CO. We
measured the percentage of myocardial necrosis, cardiac hypertrophy, hemodynamic
parameters, and the production of NO and ROS, after acute and chronic myocardial
infarction was induced in proestrus or estrus or ovariectomized female rats.
Results: The infarct area was reduced in the proestrus groups, while it
was increased in the estrus and OVX groups. The left ventricular systolic
pressure (LVSP) and