IMR Press / FBL / Volume 26 / Issue 11 / DOI: 10.52586/5008
Open Access Original Research
Aldosterone is a possible new stimulating factor for promoting vascular calcification
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1 Department of Cardiology, The First Central Clinical College of Tianjin Medical University, 300070 Tianjin, China
2 Department of Cardiology, Tianjin First Central Hospital, 300070 Tianjin, China
3 Department of Cardiology, Longgang People’s Hospital of Shenzhen, 518172 Shenzhen, Guangdong, China
4 Department of Cardiology, Dongguan Kanghua Hospital, 523080 Dongguan, Guangdong, China
5 Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University, 200072 Shanghai, China
*Correspondence: (Chengzhi Lu); (Jianshe Yang)
Front. Biosci. (Landmark Ed) 2021, 26(11), 1052–1063;
Submitted: 29 September 2021 | Revised: 25 October 2021 | Accepted: 29 October 2021 | Published: 30 November 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (

Background: Aldosterone is an important hormone in the renin-angiotensin-aldosterone system (RAAS), and playing a pivotal role in the development of hypertension, heart failure, and other cardiovascular diseases. Material and method: In this study, the role of the aldosterone in vascular calcification was underwent in rat model compared with other drugs. Vascular calcification, calcium concentration, activity of alkaline phosphatase (ALP), aldosterone, Urotensin II, mineralocorticoid receptor (MR) and Osteopontin (OPN) were detected or confirmed by the von Kossa staining, colorimetric assays, immunohistochemistry and radioimmunoassay, separately. Result: Results revealed that the aldosterone was significantly increased compared calcification + aldosterone group with calcification group, whereas it was notably decreased in calcification + Spironolactone group in the aortic wall. Compared with control group and aldosterone group, calcium content in vascular tissues was increased in calcification group and calcification + aldosterone group. As the immunoreactivity of the MR, OPN, Urotensin II, IL-6, monocyte chemoattractant protein-1, and deposition of collagen in calcification group and aldosterone group, they all were increased slightly, but were significantly increased in calcification + aldosterone group. Conclusion: It is implied that aldosterone may be involved in the development of vascular calcification, however, the mechanism needs to be further studied.

Vascular calcification
Inflammatory factor
Urotensin II
Fig. 1.
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