† These authors contributed equally.
Background: The multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) has become one of the most
important pathogens of nosocomial infection due to widespread use of broad
spectrum antimicrobial drugs and immunosuppressor therapy. As polymyxins
resistance emerges, developing novel effective antibacterial agents capable of
overcoming multidrug resistance is urgently needed. Methods: In this
study, biodegradable triblock copolymers of polyethylene glycol (PEG),
guanidinium-functionalized polycarbonate and polylactide,