IMR Press / FBL / Volume 26 / Issue 10 / DOI: 10.52586/4997
Open Access Review
Research progress in gene editing technology
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1 Shandong Provincial Key Laboratory of Plant Stress Research, College of Life Science, Shandong Normal University, 250014 Jinan, Shandong, China
2 Bellagen Biotechnology Co., Ltd., 250000 Jinan, Shandong, China
3 College of Life Sciences, Liaocheng University, 252000 Liaocheng, Shandong, China
*Correspondence: (Yanwei Lv)
These authors contributed equally.
Front. Biosci. (Landmark Ed) 2021, 26(10), 916–927;
Submitted: 1 May 2021 | Revised: 17 August 2021 | Accepted: 24 August 2021 | Published: 30 October 2021
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (

As a tool for modifying the genome, gene editing technology has developed rapidly in recent years, especially in the past two years. With the emergence of new gene editing technologies, such as transposon editing tools, numerous advancements have been made including precise editing of the genome, double base editing, and pilot editing. This report focuses on the development of gene editing tools in recent years, elaborates the progress made in classic editing tools, base editor and other new editing tools, and provides insights into challenges and opportunities.

Gene editing
Base editing
New tools
Fig. 1.
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