IMR Press / FBL / Volume 25 / Issue 9 / DOI: 10.2741/4875

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Progression of squamous cell carcinoma is regulated by miR-139-5p/CXCR4
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1 Department of Oral Surgery, Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, P. R. China
2 Department of Pediatric Dentistry, Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, P. R. China
3 Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, P. R. China
Send correspondence to: Liu Liu, Department of Oral and Maxillofacial-Head and Neck Oncology,Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Key Laboratory of Stomatology, No.639, Zhizaoju Rd, Shanghai, P. R. China, Tel:86-21-23271699, Fax:86-21-63136856, E-mail: liuliucycstal@163.com
Front. Biosci. (Landmark Ed) 2020, 25(9), 1732–1745; https://doi.org/10.2741/4875
Published: 1 June 2020
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

miR-139-5p has a tumor suppressor effect in some cancers and negatively regulates CXCR4. To this end, we examined the expression and mechanism of of action of miR-139-5p and CXCR4 in oral squamous cell carcinoma (OSCC). miRNA-139-5p was down-regulated whereas CXCR4 was increased in tissues and cells of OSCC. Moreover, low expression of miR-139-5p was associated with a low survival. Overexpression of miR-139-5p in OSCC inhibited in vitro and in vivo cell proliferation and in vitro mobility of OSCC and inhibited the expression of WNT responsive c-myc, cyclinD1, and Bcl-2, and such effects were all reversible by an inhibitor of miR-139-5p or over-expression of CXCR4. The inverse relation between expression of miR-139-5p and CXCR4 might be related to the fact that miR-139-5p negatively regulates CXCR4 expression by virtue of direct binding. These findings underscore the importance of miR-139-5p and CXCR4 in regulation of OSCC.

Keywords
Oral
Squamous Cell Carcinoma
miR-139-5p
Wnt
Beta-Catenin Signaling
Proliferation
Invasion
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