IMR Press / FBL / Volume 25 / Issue 9 / DOI: 10.2741/4870

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Role of kinases in virulence and pathogenesis of protozoan parasite E. Histolytica
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1 Jawaharlal Nehru University, New Delhi, 110067, India.
2 Jamia Millia Islamia, New Delhi, 110025, India
Send correspondence to: Samudrala Gourinath, School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India, Tel: 91 011-26704513, Fax: 91 011 2674 2516, E-mail:
Front. Biosci. (Landmark Ed) 2020, 25(9), 1617–1635;
Published: 1 March 2020
(This article belongs to the Special Issue Structural genomics of human kinome)

Protein kinases are known to regulate several cellular processes like metabolism, motility and endocytosis through phosphorylation of specific target proteins which forms a communication system relaying extracellular signals to intracellular milieu for an adaptive response. One of the protozoan parasite Entamoeba histolytica, which causes amoebiasis and is one of the prominent reason for causing diarrhoea in infants of developing countries, where it remains the third leading cause of deaths in infants(1). The genome of this parasite codes for 331 putative protein kinases which accounts for 3.7% of the proteome. The kinome of the parasite is composed of several conserved and as well as kinase with unusual domain architecture. About one-third of kinome codes for transmembrane kinases (TMK) which is proposed to help the parasite to sense and adapt to the gut environment which is constantly changing. Many kinases are known to be involved in virulence but, the kinome of this important parasite is unexplored. In this review, we present an overview of E. histolytica kinases and their role in amoebic biology understood till now.

Protozoan Parasite
Entamoeba histolytica
Virulence and signalling
Figure 1
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