IMR Press / FBL / Volume 25 / Issue 7 / DOI: 10.2741/4855

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Phytoconstituents as novel osteo-protective agents: Implications in bone health
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1 Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Central University, Sagar (MP)-470003, India
2 Department of Pharmaceutical Sciences, Dr. Harisingh Gour Central University, Sagar (MP)-470003, India
3 Chitkara School of Health Sciences, Chitkara University, Punjab-140401, India
4 Department of Biotechnology, All India Institute of Medical Sciences, (AIIMS), New Delhi-110029, India
5 Divison of Endocrinology, School of medicine, Emory University Atlanta, Georgia- 30322, USA
Send correspondence to: Rupesh K. Srivastava, Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi -110029, India, Tel: 011-26593548, Fax: 91-11-26588663, E-mail: rupesh_srivastava13@yahoo.co.in
Front. Biosci. (Landmark Ed) 2020, 25(7), 1259–1296; https://doi.org/10.2741/4855
Published: 1 March 2020
(This article belongs to the Special Issue Recent advances in Bone Biology)
Abstract

Osteoporosis is a progressive and chronic bone disorder characterized by low bone mass and microarchitectural deterioration of skeletal tissues. Osteoporosis leads to alteration in bone mineral content resulting in decreased bone strength with elevated fracture risks frequently associated with greater morbidity. The latest research in the area of photomedicine had sparked interest in harnessing the active components from plants in both disease control and management across the globe. We in the present review have taken a comprehensive approach to identify forty known plants and their phytoconstituents, which encompasses (i) the genetic diversity of various plants, (ii) their active components and (iii) their osteoprotective role in osteoporosis. Thus, the present review is an attempt for the first time to collectively document the therapeutic properties of valuable medicinal plants in preventing and treating bone loss in osteoporosis.

Keywords
Phytoconstituents
Osteoporosis
Bone health
Bone loss
Osteo-protective and Review
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