IMR Press / FBL / Volume 25 / Issue 6 / DOI: 10.2741/4848

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Instrumental role for reactive oxygen species in the inflammatory response
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1 Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
2 Departments of Pathology, Microbiology and Immunology, and Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
Front. Biosci. (Landmark Ed) 2020, 25(6), 1110–1119; https://doi.org/10.2741/4848
Published: 1 March 2020
(This article belongs to the Special Issue Pro and con iron and ROS in inflammation and infection)
Abstract

Because of their highly reactive nature and potentially toxic characteristic, reactive oxygen species (ROS) have had a bad reputation for years. However, under certain conditions, ROS generation has shown positive outcomes. It is ROS imbalance that causes toxic effects. ROS play an important role in physiological processes such as cell signaling, senescence, inflammation, and the immune response to infection. An increasing number of studies highlight the importance of ROS for the inflammatory response, whether sterile or due to infection or cancer. The purpose of this paper is to present evidence of the essential role of ROS in the inflammatory response.

Keywords
Reactive Oxygen Species
Inflammation
Infection
Cancer
Review
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