IMR Press / FBL / Volume 25 / Issue 10 / DOI: 10.2741/4884

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
MEG3 targets miR-184 and Wnt/β-catenin and modulates properties of osteosarcoma
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1 Department of Orthopaedics, Nanchong central hospital, Sichuan province, 637000, PR China
2 Department of pharmacy, Nanchong central hospital, Sichuan province, 637000, PR China
3 Department of endocrinology department, Nanchong central hospital, Sichuan province, 637000, PR China
Send correspondence to: Liang Li, Nanchong central hospital. 97 Renmin South Road, Shunqing district, Nanchong, Sichuan, PR China, Tel: 86-027-67812888, Fax: 86-027-67812888, E-mail: v2s5w0@sina.com
Front. Biosci. (Landmark Ed) 2020, 25(10), 1901–1912; https://doi.org/10.2741/4884
Published: 1 June 2020
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Recent studies indicate that MEG3, a long non-coding RNA (lncRNA) and microRNA-184 (miR-184) are abnormally expressed in osteosarcoma (OS). To this end, we show here that MEG3 negatively regulates the expression of miR-184 and down-stream effectors of WNT/β-catenin pathway including β-catenin, T-cell factor 4 (TCF4) and c-MYC. MEG3 overexpression by adenoviral vectors down-regulate proliferation, migration and apoptosis of OS in vitro and restrict the tumor growth in vivo. We also show that the effects of MEG3 can be effectively reversed by miR-184 mimic. Together these studies show that both MEG3 and miR-184 cooperatively regulate the proliferation, migration and apoptosis of OS.

Keywords
MEG3
Osteosarcoma
miR-184
Wnt/β-catenin
Figures
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