IMR Press / FBL / Volume 25 / Issue 1 / DOI: 10.2741/4797

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Drosophila melanogaster as a model for understanding polyADP-ribosylation
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1 Nagahama Institute of Bio-Science and Technology, Nagahama Shiga 526-0829, Japan
2 Institute of Basic Biological Sciences, University of Tsukuba, Tsukuba Ibaraki 305-8575, Japan
3 Center for Chronic Viral Diseases, Kagoshima University, Kagoshima, Kagoshima 890-8544, Japan
Send correspondence to: Masanao Miwa, Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga 526-0829, Japan, Tel: 81-749-64-8100, Fax: 81-749-64-8140, E-mail:
Front. Biosci. (Landmark Ed) 2020, 25(1), 118–133;
Published: 1 January 2020
(This article belongs to the Special Issue Cutting edge of insect biomedical science)

PolyADP-ribosylation is a post-translational modification which is involved in various physiological processes including maintenance of genome stability through DNA repair, regulation of transcription, and development. This process is also involved in pathological events such as cell death. Here, we review the effect of polyADP-ribosylation in signal transduction pathways in Drosophila melanogaster system. It is hoped that such an insight paves the way to develop therapeutics for human diseases.

Drosophila melanogaster
Neurodegenerative disease
Figure 1
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