IMR Press / FBL / Volume 24 / Issue 4 / DOI: 10.2741/4749

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Recent advances in the regulation of testicular germ cell tumors by microRNAs
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1 State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
2 University of Chinese Academy of Sciences, Beijing, 100049, China
3 Changsha Reproductive Medicine Hospital, Hunan, Changsha, 410205, China
4 Reproductive Medicine Center of People’s Hospital of Zhengzhou University, Zhengzhou 450003, China
5 Reproduction Medical Center, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, China
*Correspondence: chensuren@ioz.ac.cn (Su-Ren Chen)
Front. Biosci. (Landmark Ed) 2019, 24(4), 765–776; https://doi.org/10.2741/4749
Published: 1 March 2019
(This article belongs to the Special Issue Advances in mammalian reproduction)
Abstract

Testicular germ cell tumors (TGCTs) are generally rare but represent the most common solid tumors in young men. They are classified broadly into seminoma, which resemble primordial germ cells (PGCs), and non-seminoma, which are either undifferentiated (embryonic carcinoma) or differentiated (teratoma, yolk sac tumor, choriocarcinomas) patterning. A widespread role for microRNAs (miRNAs), in diverse molecular processes driving initiation and progression of various types of TGCTs has been recently studied. We discuss the involvement of different miRNAs in the development and progression of different types of TGCTs. Moreover, we highlight the aberrant expression of miRNAs in TGCTs and several targets, which may define miRNAs as oncomiRs or tumor suppressors. A better understanding of miRNA biology may ultimately yield further insight into the molecular mechanisms of tumorigenesis and new therapeutic strategies against TGCTs.

Keywords
TGCTs
microRNAs
OncomiRs
Tumor suppressor
Review
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