IMR Press / FBL / Volume 24 / Issue 4 / DOI: 10.2741/4748

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Long non-coding RNAs in biology and female reproductive disorders
Xiao-Yan Wang1,2,3,4Ying-Ying Qin1,2,3,4,*
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1 Center for Reproductive Medicine, Shandong University, Jinan China
2 Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
3 National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China
4 Key Laboratory of Reproductive Endocrinology, Shandong University, Ministry of Education, Jinan, China
*Correspondence: (Ying-Ying Qin)
Front. Biosci. (Landmark Ed) 2019, 24(4), 750–764;
Published: 1 March 2019

Accumulating data from large-scale transcriptome studies have identified a class of poorly understood non-protein-coding RNAs, including microRNAs, piwi-interacting RNAs (piRNAs), and long non-coding RNAs (lncRNAs), and a number of studies suggest that lncRNAs modulate the expression of protein-coding genes in a variety of tissues and organs by altering chromatin modification, transcription, mRNA decay, protein subcellular localization, and other key processes. Although much work still remains to identify the roles of lncRNAs in reproduction-related systems, they are likely to exert widespread effects during these processes. In this review, we highlight our emerging understanding of how lncRNAs regulate gene expression, and we discuss the physiological role of this new class of molecular regulators in neurobiology, cardiology, endocrinology, metabolism, muscle biology, and female reproductive disorders.

Long non-coding RNA
Reproductive system
Female reproductive disorders
Figure 1
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