IMR Press / FBL / Volume 24 / Issue 3 / DOI: 10.2741/4731

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


The regulatory role of coagulation factors in vascular function

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1 Center for Thrombosis and Hemostasis, University Medical Center Mainz, Germany
2 Center for Cardiology-Cardiology I, University Medical Center Mainz, Germany
3 German Center for Cardiovascular Research (DZHK), partner site Rhine-Main, University Medical Center Mainz, Germany

*Author to whom correspondence should be addressed.

Front. Biosci. (Landmark Ed) 2019, 24(3), 494–513;
Published: 1 January 2019
(This article belongs to the Special Issue Innate immune mechanisms in thrombosis and vascular biology)

The coagulation takes place in the hemostasis system and is a is hallmarked by a complex interplay of reactions between coagulation proteins. In the presence of a vascular breach, the conversion of prothrombin to thrombin leads to the formation of insoluble fibrin fibers that will stop bleeding and limit blood loss. Hemostasis is known to be disturbed in many diseases leading to hemorrhages or thrombosis. Despite the role of coagulation in hemostasis, recent evidences suggested that coagulation factors are involved in other (patho)physiological processes in the vasculature not necessarily marked by overt clotting, such as atherosclerosis and hypertension. Many direct (through protease activated receptors) or indirect effects of several coagulation factors are now well described. This review is focusing on the role of coagulation factors in the (dys)regulation of vascular function.

Tissue factor
Protease-activated receptor
Factor XI
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