IMR Press / FBL / Volume 24 / Issue 3 / DOI: 10.2741/4728

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Polarity as a physiological modulator of cell function
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1 Biomedical Engineering Program, University of South Carolina, 301 Main St, Columbia, SC 29208
2 Department of Chemical Engineering, University of South Carolina,301 Main St, Columbia SC 29208
Send correspondence to: Ehsan Jabbarzadeh, University of South Carolina 301 Main St Columbia, SC 29208, Tel: 803-777-3297, Fax: 803-777-8265, E-mail:
Front. Biosci. (Landmark Ed) 2019, 24(3), 431–442;
Published: 1 January 2019

Cell polarity, the asymmetric distribution of proteins, organelles, and cytoskeleton, plays an important role in development, homeostasis, and disease. Understanding the mechanisms that govern cell polarity is critical for creating strategies to treat developmental defects, accelerate tissue regeneration, and hinder cancer progression. This review focuses on the role of cell polarity in a number of physiological processes, including asymmetric division, cell migration, immune response mediated by T lymphocytes, and cancer progression and metastasis, and highlights microfabrication techniques to systematically parse the role of microenvironmental cues in the regulation of cell polarity.

Cell polarity
Cell fate
Cell asymmetry
Figure 1
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