IMR Press / FBL / Volume 24 / Issue 2 / DOI: 10.2741/4718

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Amelioration of prediabetes-induced changes of dendritic structural plasticity
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1 Department of Experimental Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, 710038, Shanxi, China
2 HemaCare Corporation, 15350 Sherman Way, Van Nuys, CA 91504, California, USA
3 Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, Massachusetts, USA
4 Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, 710038, Shanxi, China
5 Department of Endocrinology, Xijing Hospital, The Fourth Military Medical University, Xi’an, 710032, Shanxi, China
*Correspondence: ayonst@163.com (Yanyang Tu)
Front. Biosci. (Landmark Ed) 2019, 24(2), 291–302; https://doi.org/10.2741/4718
Published: 1 January 2019
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Accumulating evidence suggests that the diabetes-induced cognitive dysfunction can be alleviated when exposed to the enriched environment. However, the impact of the changes of the hippocampal plasticity on the cognitive decline and the possible effect of an enriched environment in prediabetes are still not clearly documented. To explore the effect of enriched environment for prediabetes-induced changes of dendritic structural plasticity in hippocampus pyramidal and cognitive deficits, the praxiology experiments for evaluating of anxiety, spatial learning and memory of prediabetic Wistar were performed, and then the dendritic spine density was assessed in the hippocampal CA1 pyramidal neuronal region. The prediabetic rats demonstrated a hyper-anxiety like behavior and significantly decreased spatial learning abilities and memory deficits. Exposing prediabetic rats to an enriched environment appeared to significantly mitigate the above changes in a time-dependent manner. The enriched environment also restored the density of the hippocampal dendritic spine which was significantly reduced in prediabetic rats. We found that the enriched environment was beneficial in overcoming the prediabetes-induced cognitive disorders and diminished dendritic plasticity of hippocampus pyramidal.

Keywords
Prediabetes
Cognitive dysfunction
Hippocampus
Enriched environment
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