IMR Press / FBL / Volume 24 / Issue 2 / DOI: 10.2741/4717

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Dysregulated circRNAs and ceRNA network in esophageal squamous cell carcinoma
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1 Department of Oncology, Huai’an First People’s Hospital, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, 223300, Jiangsu, China
2 Department of Thoracic Surgery, Huai’an First People,s Hospital, The Affiliated Huai,an No.1 People,s Hospital of Nanjing Medical University, Huai,an, 223300, Jiangsu, China
*Correspondence: tianwenze@qq.com (Wenze Tian)
Front. Biosci. (Landmark Ed) 2019, 24(2), 277–290; https://doi.org/10.2741/4717
Published: 1 January 2019
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Accumulating evidence suggests that circular RNA (circRNA), once thought to be a transcriptional error, plays an important regulatory role in the tumor biological process. Some circRNAs regulate the protein-coding gene expression by competitive binding with microRNAs (miRNAs). However, functional roles of circRNA-mediated competitive endogenous RNAs (ceRNAs) in esophageal squamous cell carcinoma (ESCC) are rarely reported. To explore the biological functions of circRNAs in ESCC, we surveyed the integrating differential circRNA expression of ESCC and para-cancer tissues using microarray in three patients. Then, we screened out differentially expressed mRNAs obtained from 81 ESCC tissues and 11 normal tissues in The Cancer Genome Atlas (TCGA). Then, we constructed a hypothetical ceRNA network by integrating differential expression of circRNAs and mRNAs. Finally, 32 differentially expressed circRNAs and 98 differentially expressed mRNAs were linked by 64 miRNAs to build the ceRNA network in ESCC. We suggest that the identified ceRNA network can facilitate a better understanding of circRNA-related mechanisms in ESCC.

Keywords
Esophageal cancer
Esophageal squamous cell carcinoma
circRNA
The Cancer Genome Atlas
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