IMR Press / FBL / Volume 23 / Issue 9 / DOI: 10.2741/4670

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Intestinal enteroendocrine L cells in amino acid sensing and diseases

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1 Laboratory of Animal Nutrition and Human Health, School of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, China
2 Human Engineering and Research Center of Animal and Poultry Science, Key Lab Agroecology Processing Subtropical Region, Scientific Observational and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha, Hunan, 410125, China
3 Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM, USA 87131, Mexico
Front. Biosci. (Landmark Ed) 2018, 23(9), 1740–1753; https://doi.org/10.2741/4670
Published: 1 March 2018
(This article belongs to the Special Issue Amino acids and their sensors)
Abstract

Enteroendocrine L cells are open-type enteroendocrine cells that play an important role in amino acid sensing. They detect amino acids by a number of membrane receptors such as calcium-sensing receptor and G protein coupled receptor family C group 6 subtype A. The receptors activate signaling pathways and trigger cellular electrical activities, inducing gut hormones secretion (glucagon-like peptide 1, glucagon-like peptide 2 and peptide YY). This review focuses on an array of findings on L cells as models, receptors and signaling pathways, electrical activities and hormones secretion in amino acid sensing. Several diseases that are closely related to L cells are also reviewed.

Keywords
Amino acid sensing
Disease
Electrical activity
Hormone secretion
Intestinal enteroendocrine cells
L cells
Review
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