IMR Press / FBL / Volume 23 / Issue 9 / DOI: 10.2741/4667

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Cadmium exposure and prostate cancer: insights, mechanisms and perspectives

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1 Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, I-95123 Catania, Italy
2 Department of Biomedical and Biotechnological Science, University of Catania, Via Santa Sofia, 97 - 95123 Catania, Italy
3 Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Occupational Medicine Section, University of Messina, 98125, Messina, Italy
Front. Biosci. (Landmark Ed) 2018, 23(9), 1687–1700;
Published: 1 March 2018
(This article belongs to the Special Issue Biochemical markers in biological fluids)

Cadmium (Cd) is a metal found in group 12 (IIB) of the periodic table of elements together with zinc, a metal with which it is often conjugated in nature. Occupational exposure to Cd occurs in many industrial settings, by cigarette smoking, diet and due to environmental pollution. International Agency for Research on Cancer and other epidemiological studies suggested that Cd can lead to prostate cancer and likely to kidney and lung cancers. Although epidemiological studies seem to point towards such an association, the in vitro studies have not been compelling. The aim of this article is to summarize current knowledge about the association of Cd exposure and prostate cancer, that suggests that new studies to show the role of Cd in the pathogenesis of prostatate cancer.

Heavy Metals
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