IMR Press / FBL / Volume 23 / Issue 8 / DOI: 10.2741/4661

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Emerging roles of CST in maintaining genome stability and human disease

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1 Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
Front. Biosci. (Landmark Ed) 2018, 23(8), 1564–1586; https://doi.org/10.2741/4661
Published: 1 March 2018
(This article belongs to the Special Issue DNA damage, DNA repair, and DNA damage response pathways)
Abstract

The human CTC1-STN1-TEN1 (CST) complex is a single-stranded DNA binding protein that shares homology with RPA and interacts with DNA polymerase alpha/primase. CST complexes are conserved from yeasts to humans and function in telomere maintenance. A common role of CST across species is in the regulation of telomere extension by telomerase and C-strand fill-in synthesis. However, recent studies also indicate that CST promotes telomere duplex replication as well the rescue of stalled DNA replication at non-telomeric sites. Furthermore, CST dysfunction and mutation is associated with several genetic diseases and cancers. In this review, we will summarize what is known about CST with a particular focus on the emerging roles of CST in DNA replication and human disease.

Keywords
CTC1
STN1
TEN1
CST
AAF
DNA replication
Telomere
Review
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