IMR Press / FBL / Volume 23 / Issue 8 / DOI: 10.2741/4654

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Impact of epigenetics in aging and age related neurodegenerative diseases

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1 Endocrine Research Facility, Dept. of Animal Sciences, Rutgers University, 67 Poultry Farm Lane, New Brunswick, NJ-08901, Canada
Front. Biosci. (Landmark Ed) 2018, 23(8), 1445–1464;
Published: 1 March 2018

Epigenetics involves multiple processes such as DNA methylation, histone code modifications, and noncoding RNAs to regulate gene expression. In recent years the implications of epigenetic mechanisms have emerged in the field of neuroscience especially in brain development, memory, learning, and various cognition processes. Epigenetics also plays a pivotal role during the aging process of the brain which has led to various age-related neurodegenerative diseases. This manuscript portrays the findings of various epigenetic mechanisms that play a critical role and their implications in aging as well as age-related neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

DNA methylation
Histone code
Micro RNA
Long non coding RNA
Neurodegenerative disease
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