IMR Press / FBL / Volume 23 / Issue 7 / DOI: 10.2741/4639

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The contribution of ovine models to perinatal respiratory physiology

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1 Neonatal Respiratory Research Unit, Departments of Pediatrics and Pharmacology, Physiology, Universite de Sherbrooke, QC, J1H 5N4, Canada
Front. Biosci. (Landmark Ed) 2018, 23(7), 1195–1219; https://doi.org/10.2741/4639
Published: 1 January 2018
(This article belongs to the Special Issue Perinatal injury: mechanisms and therapeutic approaches)
Abstract

The dramatic transition to air breathing at birth represents a true challenge for the newborn infant mammal, a period in which neonatal respiratory diseases are common. Since the 1930s, fetal and newborn lambs have been the model of choice for whole-animal studies on neonatal respiration. The present review aims to illustrate the relevance of ovine models in studying the establishment of successful breathing at birth and its maintenance in the early postnatal period, as well as a number of abnormal conditions that can interfere with these processes.

Keywords
Respiration
Fetus
Newborn
Ovine models
Review
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