IMR Press / FBL / Volume 23 / Issue 5 / DOI: 10.2741/4629

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Leishmaniasis treatment: update of possibilities for drug repurposing

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1 Laboratorio de Bioquimica de Tripanosomatideos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brasil
Front. Biosci. (Landmark Ed) 2018, 23(5), 967–996; https://doi.org/10.2741/4629
Published: 1 January 2018
Abstract

The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by Leishmania parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is in-efficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases. The discovery of new clinical applications for approved drugs is strategic for lowering the cost of drug discovery since human toxicity assays are already conducted. Here, we review a broad analysis of the different aspects of this approach for anti-leishmanial treatment.

Keywords
Leishmaniasis
Treatment
Drug Repurposing
Review
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