IMR Press / FBL / Volume 23 / Issue 4 / DOI: 10.2741/4615

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Role of pericytes in vascular immunosurveillance

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1 Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universitat, Munich, Germany
2 German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany
Front. Biosci. (Landmark Ed) 2018, 23(4), 767–781;
Published: 1 January 2018
(This article belongs to the Special Issue Innate immune mechanisms in thrombosis and vascular biology)

Pericytes build together with endothelial cells the microvascular vessel wall. They have been mainly implicated in angiogenesis and maintenance of the blood brain barrier, but there is accumulating evidence for an immunological function of pericytes. Occupying a strategic position between the blood stream and the interstitial space, pericytes are able to sense environmental cues from both sides in an organ-specific manner and serve as gatekeepers for innate immune cells. In addition, pericytes are able to interact with leukocytes mediated by adhesion molecules as well as chemokines and are involved from the development of leukocytes in the bone marrow to their migration to injured or infected areas in target tissues. During disease processes pericytes regulate blood flow, vascular permeability, and leukocyte recruitment, but also contribute to maladaptive tissue responses, such as fibrosis making pericytes an attractive therapeutic target.

Leukocyte Migration
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