IMR Press / FBL / Volume 23 / Issue 4 / DOI: 10.2741/4613

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The biology of the platelet with special reference to inflammation, wound healing and immunity

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1 Institut Hospital-Universitaire LIRYC, Plateforme Technologique d’Innovation Biomédicale, Hospital Xavier Arnozan, Pessac, France
Front. Biosci. (Landmark Ed) 2018, 23(4), 726–751; https://doi.org/10.2741/4613
Published: 1 January 2018
(This article belongs to the Special Issue Molecular pathways of aging and longevity)
Abstract

While platelets have long been known to be essential for maintaining hemostasis in the vasculature, their role in tissue repair, inflammation and innate and adaptive immunity is a more recent science. The ability of platelets to attach to the vessel wall, form aggregates and promote fibrin formation, key elements of blood clotting, has been said to both favor and dampen inflammation, to fight infection and to assure an adequate immune response. To fulfill their different roles platelets often synchronize with leukocytes and cells of the immune system. But just as the molecular pathways of platelets in preventing blood loss can lead to arterial thrombosis and stroke if occurring in an uncontrolled manner, the failure to control inflammation can lead to sepsis and inadequate platelet function and can aggravate many major illnesses. This review is aimed to present a global picture of multifaceted platelet biology and platelet involvement in selected non-hemostatic events.

Keywords
Platelet
Inflammation
Wound Healing
Immunity
Review
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