IMR Press / FBL / Volume 23 / Issue 4 / DOI: 10.2741/4612

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Medical imaging diagnosis of early Alzheimer’s disease

Show Less
1 Information Technology Department, Faculty of Computers and Information, Mansoura University, 35516, Mansoura, Egypt
2 BioImaging Laboratory, Department of Bioengineering, University of Louisville, 40292, USA
3 Department of Electrical and Computer Engineering, Abu Dhabi University, USA
4 School of Medicine, University of South Carolina, 29208, Greenville, South Carolina, USA
5 University of Louisville Autism Center, Department of Neurology, University of Louisville, 40217, Louisville, KY, USA
Front. Biosci. (Landmark Ed) 2018, 23(4), 671–725;
Published: 1 January 2018

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases that influences the central nervous system, often leading to dire consequences for quality of life. The disease goes through some stages mainly divided into early, moderate, and severe. Among them, the early stage is the most important as medical intervention has the potential to alter the natural progression of the condition. In practice, the early diagnosis is a challenge since the neurodegenerative changes can precede the onset of clinical symptoms by 10–15 years. This factor along with other known and unknown ones, hinder the ability for the early diagnosis and treatment of AD. Numerous research efforts have been proposed to address the complex characteristics of AD exploiting various tests including brain imaging that is massively utilized due to its powerful features. This paper aims to highlight our present knowledge on the clinical and computer-based attempts at early diagnosis of AD. We concluded that the door is still open for further research especially with the rapid advances in scanning and computer-based technologies.

Alzheimer’s disease
Early Diagnosis
Medical Imaging Modalities
Clinical Findings
Computer-Based Findings
Back to top