IMR Press / FBL / Volume 23 / Issue 4 / DOI: 10.2741/4610

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Homeostatic regulation of plasma amino acid concentrations

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1 Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS 39762-9815, USA
2 Department of Animal Science, Texas A and M University, College Station, TX 77843-2471, USA
Front. Biosci. (Landmark Ed) 2018, 23(4), 640–655;
Published: 1 January 2018

One major goal of nutrition is to maximize the rate of muscle protein gain via provision of amino acids (AAs) through blood plasma. Comparing the plasma AA concentrations with the growth performance data can help to elucidate the metabolic mechanisms regulating plasma AA homeostasis, nutrient utilization, and intracellular protein turnover. Knowledge about the homeostatic regulation of plasma AA profile can aid in predicting dietary AA availabilities, the order of limiting AAs, and the whole body protein metabolism. Lysine, for example, is typically the first limiting AA in practical swine diets; however, our current knowledge is insufficient to draw a clear conclusion about the complex relationship between dietary lysine supply and plasma AA profiles. Thorough understanding of the effect of dietary AA supply on plasma AA profiles can help nutritionists to develop novel nutritional strategies to guide and improve dietary AA supplies. Further research is needed to study how different levels of dietary AAs, individually or in concert, affect the plasma concentrations of all AAs and related metabolites.

Amino acid
Blood plasma
Homeostatic regulation
Dietary supply
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