IMR Press / FBL / Volume 22 / Issue 9 / DOI: 10.2741/4551

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


TRPM2: a potential drug target to retard oxidative stress

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1 Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, Hunan 410125, Peoples R China
2 Xiangyang Central Hospital, the Affliated Hospital of Hubei University of Arts and Science, Xiangyang, 441021, Peoples R China
3 College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China
4 University of Chinese Academy of Sciences, Beijing 100049, Peoples R China
5 Department of Cardiology, Tianjin Medical University General Hospital, Tianjin Medial University, Tianjin 300052, China
6 Hunan Co-Innovation Center of Animal Production Safety, CICAPS, Changsha, 410128, Peoples R China
Front. Biosci. (Landmark Ed) 2017, 22(9), 1427–1438;
Published: 1 March 2017

The Transient Receptor Potential Melastatin 2 (TRPM2) is a member of G protein coupled receptor superfamily and a novel dual-function protein that possesses both ion channel and Adenosine 5’-DiphosPhatase Ribose (ADPR) hydrolase function. TRPM2 is involved in Ca2+ signaling in various cells as an endogenous redox sensor for oxidative stress and reactive oxygen species, and contributes to cytokine production, insulin release, motility, Ca2+ entry and Ca2+-dependent cellular reactions such as endothelial hyper-permeability and apoptosis. The wide expression of TRPM2 might render it as a potentially significant therapeutic target in pathological settings including cardiovascular and neurodegenerative diseases and of great relevance in drug design, feed additives and other industries. Here, we discuss the TRPM2 gene structure, function, its variants, as well as its activators and inhibitors and provide a peptide drug design for modulation of oxidative stress.

Transient receptor potential melastatin 2
Oxidative stress
Calcium-permeable channel
Drug design
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