IMR Press / FBL / Volume 22 / Issue 8 / DOI: 10.2741/4548

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Assessing the potential function of ADAR1 in virus-associated sepsis

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1 Emergency Department, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, No 301, Mid Yangchang Road, Shanghai, China

Academic Editor: Fei He

Front. Biosci. (Landmark Ed) 2017, 22(8), 1355–1364; https://doi.org/10.2741/4548
Published: 1 March 2017
(This article belongs to the Special Issue Targeting myeloid differentiation 2 for treatment of sepsis)
Abstract

Sepsis syndrome is a common and frequently fatal clinical condition. It is defined by the presence of both infection and an uncontrolled systemic inflammatory response. It represents a major, although largely unappreciated, healthcare problem worldwide. It is especially problematic in infants and toddlers who show markedly increased susceptibility to severe infections caused by various pathogens, including viruses. Viruses are important causative agents of sepsis. Host adenosine deaminase acting on RNA 1 (ADAR1) catalyzes adenosine to inosine (A-to-I) editing of RNA transcripts, thus changing viral RNAs and exerting antiviral and proviral effects. In addition, ADAR1 promotes viral replication by directly interacting with protein kinase R and suppressing its kinase activity. We here discuss the function of ADAR1 and its regulatory role in viral infection. Further, we establish the relationship between ADAR1 and virus-associated sepsis, thus providing an important basis for the development of novel therapeutic targets for the treatment of virus-associated sepsis.

Keywords
ADAR1
Sepsis
Virus
HSV
HIV-1
Review
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