IMR Press / FBL / Volume 22 / Issue 5 / DOI: 10.2741/4525

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Mitochondrial DNA repair and damage tolerance

Show Less
1 Department of Biology, University of Rochester, Rochester, NY, USA

Academic Editor: Mikhail F Alexeyev

Front. Biosci. (Landmark Ed) 2017, 22(5), 920–943; https://doi.org/10.2741/4525
Published: 1 January 2017
(This article belongs to the Special Issue Mitochondrial DNA)
Abstract

The accurate maintenance of mitochondrial DNA (mtDNA) is required in order for eukaryotic cells to assemble a functional electron transport chain. This independently-maintained genome relies on nuclear-encoded proteins that are imported into the mitochondria to carry out replication and repair processes. Decades of research has made clear that mitochondria employ robust and varied mtDNA repair and damage tolerance mechanisms in order to ensure the proper maintenance of the mitochondrial genome. This review focuses on our current understanding of mtDNA repair and damage tolerance pathways including base excision repair, mismatch repair, homologous recombination, non-homologous end joining, translesion synthesis and mtDNA degradation in both yeast and mammalian systems.

Keywords
Review
Mitochondrial DNA
mtDNA
DNA Repair
Base Excision Repair
BER
Mismatch Repair
MMR
Homologous Recombination
HR
Non-homologous End Joining
NHEJ
mtDNA Degradation
Translesion Synthesis
TLS
Microhomology-mediated End Joining
MMEJ
Yeast
Share
Back to top