IMR Press / FBL / Volume 22 / Issue 5 / DOI: 10.2741/4515

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Racial disparities in prostate cancer: a molecular perspective

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1 Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA
2 Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama, USA
3 Department of Pathology, College of Medicine, University of South Alabama, Mobile, Alabama, USA

Academic Editors: Ajay Pratap Singh, Seema Singh

Front. Biosci. (Landmark Ed) 2017, 22(5), 772–782; https://doi.org/10.2741/4515
Published: 1 January 2017
Abstract

Prostate cancer incidence and mortality rates are remarkably higher in African-American men as compared to their European-Americans counterparts. Despite these recognitions, precise causes underlying such prevalent racial disparities remain poorly understood. Although socioeconomic factors could account for such differences up to a certain extent, it is now being increasingly realized that such disparity has a molecular basis. Indeed, several differences, including genetic polymorphism, gene mutations, epigenetic modifications, miRNAs alterations, etc., have been reported in malignant prostate tissues from patients of diverse racial backgrounds. Here, we attempt to provide a molecular perspective on prostate cancer racial disparities by gathering available information on these associated factors and discussing their potential significance in disproportionate incidence and clinical outcomes.

Keywords
Prostate Cancer
Racial Disparities
Genetics
miRNAs
Growth Factors
Inflammatory Signaling
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